HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromophenacyl bromide → HCID 59610929, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromophenacyl bromide | HCID 7454 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (2S,4S)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid | HCID 688614 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | Sodium chloride; water | HCID 57417360 | — |
| Product | HCID 59610929 | HCID 59610929 | 83.7% |
Reaction Steps
To a solution of 2-bromo-1-(4-bromophenyl)ethanone (3.6 g, 12.98 mmol) and (2S,4S)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid (2.0 g, 8.65 mmol) in MeCN (50 mL) was added Et3N (1.8 mL, 12.98 mmol). After 3 h, the solution was diluted with EtOAc, sat. NaHCO3, brine, dried over MgSO4, and concentrated. The residue was taken on crude to yield product (3.1 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09156823B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-229a5e2aa3fd4b0f936fba63e618b32f |
| Source note | uspto-grants-2015_10 |