HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1751335Generated: October 28, 2026
4-Bromophenacyl bromide → HCID 69673289, compound
https://huagongshe.com/reaction/1751335
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Bromophenacyl bromide | HCID 7454 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (2S)-1-(tert-Butoxycarbonyl)-2,3-dihydro-1H-indole-2-carboxylic acid | HCID 2755955 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | Sodium chloride; water | HCID 57417360 | — |
| Product | HCID 69673289 | HCID 69673289 | — |
Reaction Steps
To a solution of (S)-1-(tert-butoxycarbonyl)indoline-2-carboxylic acid (1.61 g, 6.11 mmol) and 2-bromo-1-(4-bromophenyl)ethanone (2.55 g, 9.17 mmol) in MeCN (25 mL) was added Et3N (1.27 mL, 9.17 mmol). The solution was heated to 55° C. and stirred o/n. The solution was cooled to rt, diluted with EtOAc, sat. NaHCO3, brine, dried with MgSO4, and concentrated. The residue was taken onto the next step crude.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09156823B2 |
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| Source dataset | uspto-grants-2015_10 |
|---|
| ORD ID | ord-066fd6372ed14d02b08e01ff46a81305 |
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| Source note | uspto-grants-2015_10 |
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