Pyridinium hydrochloride → HCID 69673855, compound

Participants

Reaction Steps

8-chloro-3-methoxy-6H-benzo[c]chromene (670 mg, 2.7 mmol) and piridinium hydrochloride (3.16 g, 27.3 mmol) were heated to 185° C. for 2.5 hours. After cooling to room temperature, the reaction was diluted with water extracted into ethyl acetate. The organics were washed with water and brine, dried (Na2SO4), and concentrated. The crude residue was purified by flash chromatography to yield 8-chloro-6H-benzo[c]chromen-3-ol (523 mg, 82%)

Provenance & Evidence