1-[(Tert-butoxy)carbonyl]pyrrolidine-2-carboxylic acid → HCID 178502466, compound

HRID 1751396Notes

Reaction equation

HRID 1751396 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[C:13]1[NH:14][C:15]([C:18]2[CH:27]=[CH:26][C:25]3[C:20](=[CH:21][CH:22]=[C:23]([C:28]4[CH:33]=[CH:32][C:31]([C:34]5[NH:35][C:36]([CH:39]6[CH2:43][CH2:42][CH2:41][N:40]6[C:44](=[O:54])[CH:45]([NH:49][C:50]([O:52][CH3:53])=[O:51])[CH:46]([CH3:48])[CH3:47])=[N:37][CH:38]=5)=[CH:30][CH:29]=4)[CH:24]=3)[CH:19]=2)=[CH:16][N:17]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C([O:59]C(N1CCCC1C(O)=O)=O)(C)(C)C>>[OH:59][C@@H:42]1[CH2:41][N:40]([C:44](=[O:54])[C@@H:45]([NH:49][C:50]([O:52][CH3:53])=[O:51])[CH:46]([CH3:47])[CH3:48])[C@H:39]([C:36]2[NH:37][CH:38]=[C:34]([C:31]3[CH:30]=[CH:29][C:28]([C:23]4[CH:24]=[C:25]5[C:20](=[CH:21][CH:22]=4)[CH:19]=[C:18]([C:15]4[NH:14][C:13]([C@@H:9]6[CH2:10][CH2:11][CH2:12][N:8]6[C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])=[N:17][CH:16]=4)[CH:27]=[CH:26]5)=[CH:33][CH:32]=3)[N:35]=2)[CH2:43]1

Participants

3

Reactant 2

HCID 2684721-[(Tert-butoxy)carbonyl]pyrrolidine-2-carboxylic acidHCID 69672730HCID 69672730, compound

Product 1

HCID 178502466HCID 178502466, compound

Procedure

(S)-tert-butyl 2-(5-(6-(4-(2-((2S,4S)-4-hydroxy-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazol-4-yl)phenyl)naphthalen-2-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate was prepared following the procedure for 2-{5-[6-(4-{2-[1-(2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-phenyl)-naphthalen-2-yl]-1H-imidazol-2-yl}-pyrrolidine-1-carboxylic acid tert-butyl ester (Example EQ), substituting 4-Hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester for Pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester.

Sources & evidence

ORD record
ord-59643dfeef184756811dd128d26a8250
Source dataset
uspto-grants-2015_10
Patent number
US09156823B2

Reaction notes

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