N-Methoxycarbonyl-2-phenylglycine → HCID 178502152, compound

HRID 1751412Notes

Reaction equation

COC(=O)NC(C([N:11]1[CH2:15][CH2:14][CH2:13][CH:12]1[C:16]1[NH:20][C:19]2[CH2:21][O:22][C:23]3[CH:24]=[C:25]([C:29]4[CH:38]=[CH:37][C:36]5[C:31](=[CH:32][CH:33]=[C:34]([C:39]6[NH:40][C:41]([CH:44]7[CH2:48][CH2:47][CH2:46][N:45]7[C:49](=[O:62])[CH:50]([NH:57][C:58]([O:60][CH3:61])=[O:59])[C:51]7[CH:56]=CC=C[CH:52]=7)=[N:42][CH:43]=6)[CH:35]=5)[CH:30]=4)[CH:26]=[CH:27][C:28]=3[C:18]=2[N:17]=1)=O)C(C)C.[CH3:64][O:65][C:66]([NH:68][CH:69]([C:73]1[CH:78]=[CH:77][CH:76]=[CH:75][CH:74]=1)[C:70]([OH:72])=O)=[O:67]>>[CH3:61][O:60][C:58](=[O:59])[NH:57][CH:50]([C:49]([N:45]1[CH2:46][CH2:47][CH2:48][CH:44]1[C:41]1[NH:40][C:39]([C:34]2[CH:33]=[CH:32][C:31]3[C:36](=[CH:37][CH:38]=[C:29]([C:25]4[CH:26]=[CH:27][C:28]5[C:18]6[NH:17][C:16]([CH:12]7[CH2:13][CH2:14][CH2:15][N:11]7[C:70](=[O:72])[CH:69]([NH:68][C:66]([O:65][CH3:64])=[O:67])[C:73]7[CH:78]=[CH:77][CH:76]=[CH:75][CH:74]=7)=[N:20][C:19]=6[CH2:21][O:22][C:23]=5[CH:24]=4)[CH:30]=3)[CH:35]=2)=[CH:43][N:42]=1)=[O:62])[CH:51]([CH3:56])[CH3:52]

Participants

Reactant 2

HCID 596264N-Methoxycarbonyl-2-phenylglycine

HCID 86708733(1-{2-[7-(6-{2-[1-(2-Methoxycarbonylamino-2-phenyl-acetyl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-naphthalen-2-yl)-3,4-dihydro-chromeno[3,4-d]imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Product 1

HCID 178502152HCID 178502152, compound

Procedure

Synthesized similar to (1-{2-[7-(6-{2-[1-(2-Methoxycarbonylamino-2-phenyl-acetyl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-naphthalen-2-yl)-3,4-dihydro-chromeno[3,4-d]imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester with the corresponding methoxycarbonylamino-phenyl-acetic acid replacement.

Sources & evidence

ORD record: ord-46740bb575164ba4b20465319aa6d4b6
Source dataset: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09156823B2

Reaction notes

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