(2S)-2-((methoxycarbonyl)amino)-3-methylbutanoic acid → HCID 178502323, compound

HRID 1751437Notes

Reaction equation

HRID 1751437 reaction equation
[CH3:1][O:2][C:3]([NH:5][C@@H:6]([CH:58]([CH3:60])[CH3:59])[C:7]([N:9]1[C@H:14]([C:15]2[NH:19][C:18]3[C:20]4[C:25]([CH:26]=[CH:27][C:17]=3[N:16]=2)=[CH:24][C:23]([C:28]2[CH:29]=[C:30]3[C:54](=[CH:55][CH:56]=2)[C:34]2[NH:35][C:36]([C@@H:38]5[CH2:42][CH2:41][CH2:40][N:39]5[C:43](=[O:53])[C@@H:44]([NH:48][C:49](=[O:52])[O:50][CH3:51])[CH:45]([CH3:47])[CH3:46])=[N:37][C:33]=2[CH:32]=[CH:31]3)=[CH:22][CH:21]=4)[C@@H:13]2[CH2:57][C@H:10]1[CH2:11][CH2:12]2)=[O:8])=[O:4].[CH3:61][O:62][C:63](N[C@@H](C(C)C)C(O)=O)=O>>[CH3:1][O:2][C:3]([NH:5][C@@H:6]([CH:58]1[CH2:60][CH2:63][O:62][CH2:61][CH2:59]1)[C:7]([N:9]1[C@H:14]([C:15]2[NH:19][C:18]3[C:20]4[C:25]([CH:26]=[CH:27][C:17]=3[N:16]=2)=[CH:24][C:23]([C:28]2[CH:29]=[C:30]3[C:54](=[CH:55][CH:56]=2)[C:34]2[NH:35][C:36]([C@@H:38]5[CH2:42][CH2:41][CH2:40][N:39]5[C:43](=[O:53])[C@@H:44]([NH:48][C:49](=[O:52])[O:50][CH3:51])[CH:45]([CH3:47])[CH3:46])=[N:37][C:33]=2[CH:32]=[CH:31]3)=[CH:22][CH:21]=4)[C@@H:13]2[CH2:57][C@H:10]1[CH2:11][CH2:12]2)=[O:8])=[O:4]

Participants

3

Reactant 2

HCID 10942966(2S)-2-((methoxycarbonyl)amino)-3-methylbutanoic acidHCID 178502324HCID 178502324, compound

Product 1

HCID 178502323HCID 178502323, compound

Procedure

Title compound was prepared by methods analogous to those described for methyl (S)-1-((S)-2-(2′-((1R,3S,4S)-2-((S)-2-methoxycarbonylamino-3-methylbutanoyl)-2-azabicyclo[2.2.1]heptan-3-yl)-1H,1′H-7,7′-binaphtho[1,2-d]imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate, substituting (S)-2-(methoxycarbonylamino)-2-(tetrahydro-2H-pyran-4-yl)acetic acid for (S)-2-(methoxycarbonylamino)-3-methylbutanoic acid. (ESI) m/z 855 [M+H]+.

Sources & evidence

ORD record
ord-f8c62986539649cfbeafe209e93153af
Source dataset
uspto-grants-2015_10
Patent number
US09156823B2

Reaction notes

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