2-Aminoindane-2-carboxylic acid → HCID 69675414, compound

HRID 1751450Notes

Reaction equation

HRID 1751450 reaction equation
COC(=O)NC1([C:14]([N:16]2[CH2:20][CH2:19][CH2:18][CH:17]2[C:21]2[NH:22][C:23]([C:26]3[CH:31]=[CH:30][C:29]([C:32]4[CH:41]=[CH:40][C:39]5[C:34](=[CH:35][CH:36]=[C:37]([C:42]6[NH:43][C:44]([CH:47]7[CH2:51][CH2:50][CH2:49][N:48]7[C:52](=[O:62])[CH:53]([NH:57][C:58]([O:60][CH3:61])=[O:59])[CH:54]([CH3:56])[CH3:55])=[N:45][CH:46]=6)[CH:38]=5)[CH:33]=4)=[CH:28][CH:27]=3)=[CH:24][N:25]=2)=[O:15])CC2C(=CC=CC=2)C1.N[C:65]1(C(O)=O)[CH2:73][C:72]2[C:67](=[CH:68][CH:69]=[CH:70][CH:71]=2)[CH2:66]1>>[CH3:61][O:60][C:58](=[O:59])[NH:57][C:73]1([C:14]([N:16]2[CH2:20][CH2:19][CH2:18][CH:17]2[C:21]2[NH:22][C:23]([C:26]3[CH:31]=[CH:30][C:29]([C:32]4[CH:41]=[CH:40][C:39]5[C:34](=[CH:35][CH:36]=[C:37]([C:42]6[NH:43][C:44]([CH:47]7[CH2:51][CH2:50][CH2:49][N:48]7[C:52](=[O:62])[CH:53]([NH:57][C:58]([O:60][CH3:61])=[O:59])[CH:54]([CH3:56])[CH3:55])=[N:45][CH:46]=6)[CH:38]=5)[CH:33]=4)=[CH:28][CH:27]=3)=[CH:24][N:25]=2)=[O:15])[C:72]2[C:67](=[CH:68][CH:69]=[CH:70][CH:71]=2)[CH2:66][CH2:65]1

Participants

3

Reactant 2

HCID 2509362-Aminoindane-2-carboxylic acidHCID 86708745HCID 86708745, compound

Product 1

HCID 69675414HCID 69675414, compoundYield 38%

Procedure

[1-(2-{5-[4-(6-{2-[1-(2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-naphthalen-2-yl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carbonyl)-indan-1-yl]-carbamic acid methyl ester (0.13 g, 38%) was prepared following the procedure for [2-(2-{5-[4-(6-{2-[1-(2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-naphthalen-2-yl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carbonyl)-indan-2-yl]-carbamic acid methyl ester, substituting 1-Amino-indan-1-carboxylic acid for 2-Amino-indan-2-carboxylic acid. LCMS-ESI+: calc'd for C49H52N8O6: 848.40 (M+); Found: 849.91 (M+H+).

Sources & evidence

ORD record
ord-4ba7998e01c54b92b2a8aec984b12eb2
Source dataset
uspto-grants-2015_10
Patent number
US09156823B2

Reaction notes

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