HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-2-phenylpropanoic acid → 4-(Carboxy-methoxycarbonylamino-methyl)-piperidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-2-phenylpropanoic acid | HCID 31722 | — |
| Reactant | 2-Methoxycarbonylamino-2-phenyl-propionic acid | HCID 62489741 | — |
| Product | 4-(Carboxy-methoxycarbonylamino-methyl)-piperidine-1-carboxylic acid tert-butyl ester | HCID 69672138 | 97% |
Reaction Steps
4-(Carboxy-methoxycarbonylamino-methyl)-piperidine-1-carboxylic acid tert-butyl ester (1.2 g, 97%) was prepared following the procedure for 2-Methoxycarbonylamino-2-phenyl-propionic acid, substituting 4-(Amino-carboxy-methyl)-piperidine-1-carboxylic acid tert-butyl ester for 2-Amino-2-phenyl-propionic acid. LCMS-ESI+: calc'd for C14H24N2O6: 316.16 (M+); Found: 339.02 (M+Na+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09156823B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-6939f16e9e4d486ea609cbfaeabc907e |
| Source note | uspto-grants-2015_10 |