Propionyl chloride → HCID 178502180, compound
Reaction equation
[CH3:1][O:2][C:3](=[O:66])[NH:4][CH:5]([C:60]1[CH:65]=[CH:64][CH:63]=[CH:62][CH:61]=1)[C:6](=[O:59])[N:7]1[CH2:11][CH2:10][CH2:9][CH:8]1[C:12]1[NH:13][C:14]([C:17]2[CH:26]=[CH:25][C:24]3[C:19](=[CH:20][CH:21]=[C:22]([C:27]4[CH:28]=[C:29]5[C:56](=[CH:57][CH:58]=4)[C:33]4[NH:34][C:35]([CH:37]6[CH2:41][CH2:40][CH2:39][N:38]6[C:42](=[O:55])[CH:43]([NH:50][C:51](=[O:54])[CH2:52][CH3:53])[CH:44]6[CH2:49][CH2:48][O:47][CH2:46][CH2:45]6)=[N:36][C:32]=4[CH2:31][CH2:30]5)[CH:23]=3)[CH:18]=2)=[CH:15][N:16]=1.[C:67](Cl)(=O)CC>>[CH3:1][O:2][C:3](=[O:66])[NH:4][CH:5]([C:60]1[CH:65]=[CH:64][CH:63]=[CH:62][CH:61]=1)[C:6]([N:7]1[CH2:11][CH2:10][CH2:9][CH:8]1[C:12]1[NH:13][C:14]([C:17]2[CH:26]=[CH:25][C:24]3[C:19](=[CH:20][CH:21]=[C:22]([C:27]4[CH:28]=[C:29]5[C:56](=[CH:57][CH:58]=4)[C:33]4[NH:34][C:35]([CH:37]6[CH2:41][CH2:40][CH2:39][N:38]6[C:42](=[O:55])[CH:43]([NH:50][C:51]([CH:52]6[CH2:67][CH2:53]6)=[O:54])[CH:44]6[CH2:49][CH2:48][O:47][CH2:46][CH2:45]6)=[N:36][C:32]=4[CH2:31][CH2:30]5)[CH:23]=3)[CH:18]=2)=[CH:15][N:16]=1)=[O:59]Participants
3
Procedure
[2-(2-{5-[6-(2-{1-[2-(Cyclopropanecarbonyl-amino)-2-(tetrahydro-pyran-4-yl)-acetyl]-pyrrolidin-2-yl}-4,5-dihydro-1H-naphtho[1,2-d]imidazol-7-yl)-naphthalen-2-yl]-1H-imidazol-2-yl}-pyrrolidin-1-yl)-2-oxo-1-phenyl-ethyl]-carbamic acid methyl ester (0.01 g, 38%) was prepared following the procedure for [2-Oxo-1-phenyl-2-(2-{5-[6-(2-{1-[2-propionylamino-2-(tetrahydro-pyran-4-yl)-acetyl]-pyrrolidin-2-yl}-4,5-dihydro-1H-naphtho[1,2-d]imidazol-7-yl)-naphthalen-2-yl]-1H-imidazol-2-yl}-pyrrolidin-1-yl)-ethyl]-carbamic acid methyl ester, substituting Cyclopropanecarbonyl chloride for Propionyl chloride. LCMS-ESI+: calc'd for C53H56N8O6: 900.43 (M+); Found: 902.07 (M+H+).
Sources & evidence
- ORD record
- ord-d10db2cbcf884f9a8a7e1b1bfc3dcdc9
- Source dataset
- uspto-grants-2015_10
- Patent number
- US09156823B2
Reaction notes
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