HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[(Tert-butoxy)carbonyl]pyrrolidine-2-carboxylic acid → HCID 66981804, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[(Tert-butoxy)carbonyl]pyrrolidine-2-carboxylic acid | HCID 268472 | — |
| Reactant | 2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 54775623 | — |
| Product | HCID 66981804 | HCID 66981804 | 60% |
Reaction Steps
3-[5-(4-Bromo-phenyl)-1H-imidazol-2-yl]-2-aza-bicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester (0.16 g, 60%) was prepared following the procedure for 2-[5-(4-Bromo-phenyl)-1H-imidazol-2-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester, substituting 2-Aza-bicyclo[3.1.0]hexane-2,3-dicarboxylic acid 2-tert-butyl ester for Pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester. LCMS-ESI+: calc'd for C19H22BrN3O2: 403.09 (M+); Found: 404.76 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09156823B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-2481aa12b44444598467a1ebd3c7a47e |
| Source note | uspto-grants-2015_10 |