1-(tert-Butoxycarbonyl)-4-methylenepyrrolidine-2-carboxylic acid → HCID 69676375, compound

HRID 1751487Notes

Reaction equation

HRID 1751487 reaction equation
COC(=O)NC(C(N1CCCC1C1[NH:17][C:18]([C:21]2[CH:26]=[CH:25][C:24]([B:27]3[O:31][C:30]([CH3:33])([CH3:32])[C:29]([CH3:35])([CH3:34])[O:28]3)=[CH:23][CH:22]=2)=[CH:19][N:20]=1)=O)C(C)C.[C:37]([O:41][C:42]([N:44]1[CH2:48][C:47](=[CH2:49])[CH2:46][CH:45]1[C:50](O)=O)=[O:43])([CH3:40])([CH3:39])[CH3:38]>>[C:37]([O:41][C:42]([N:44]1[CH2:48][C:47](=[CH2:49])[CH2:46][CH:45]1[C:50]1[NH:17][C:18]([C:21]2[CH:22]=[CH:23][C:24]([B:27]3[O:31][C:30]([CH3:33])([CH3:32])[C:29]([CH3:35])([CH3:34])[O:28]3)=[CH:25][CH:26]=2)=[CH:19][N:20]=1)=[O:43])([CH3:38])([CH3:39])[CH3:40]

Participants

3

Reactant 2

HCID 217625641-(tert-Butoxycarbonyl)-4-methylenepyrrolidine-2-carboxylic acidHCID 66619939[2-Methyl-1-(2-{4-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl)-propyl]-carbamic acid methyl ester

Product 1

HCID 69676375HCID 69676375, compound

Procedure

This compound was made using the same procedure used to make [2-Methyl-1-(2-{5-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carbonyl)-propyl]-carbamic acid methyl ester using 4-Methylene-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester. LCMS-ESI+: calc'd for C25H34BN3O4: 451.26 (M+); Found: 452.33 (M+H+).

Sources & evidence

ORD record
ord-b2301ec1eaa64009af74c5022e14c7fe
Source dataset
uspto-grants-2015_10
Patent number
US09156823B2

Reaction notes

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