Citric Acid → N-[5-(4-Bromophenyl)-6-chloro-4-pyrimidinyl]-N'-(phenylmethyl)sulfamide

HRID 175155Notes

Reaction equation

HRID 175155 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[c:9]([Cl:15])[n:10][cH:11][n:12][c:13]2[Cl:14])[cH:6][cH:7]1.[CH2:17]([c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[NH:24][S:25](=[O:26])(=[O:27])[NH2:28].[CH3:29][S:30]([CH3:31])=[O:32].[K:16].[OH:33][C:34]([CH2:35][C:36]([C:37](=[O:38])[OH:39])([CH2:40][C:41](=[O:42])[OH:43])[OH:44])=[O:45]>>[Br:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[c:9]([Cl:15])[n:10][cH:11][n:12][c:13]2[NH:28][S:25]([NH:24][CH2:17][c:18]2[cH:19][cH:20][cH:21][cH:22][cH:23]2)(=[O:26])=[O:27])[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 311Citric AcidHCID 679Dimethyl SulfoxideHCID 5462222PotassiumHCID 12354987N-benzylaminosulfonamideHCID 197352625-(4-Bromophenyl)-4,6-dichloropyrimidine

Product 1

HCID 21041369N-[5-(4-Bromophenyl)-6-chloro-4-pyrimidinyl]-N'-(phenylmethyl)sulfamide

Sources & evidence

ORD record
ord-cf0fab4f400741219216c7d28964cb5f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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