HRID1751558

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：COC(=O)N[C@H](C(=O)N1CC(=O)C[C@H]1C(=O)OCc1ccccc1)C(C)C

HCID59610664

未命名化合物

反应SMILES：COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc2ccc(-c3ccc4c(c3)C(F)(F)c3cc(-c5cnc([C@@H]6CCCN6)[nH]5)ccc3-4)cc2[nH]1)C1CCOCC1.Cl.Cl.Cl

HCID131733627

未命名化合物

PRODUCTS

产物

反应SMILES：COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc(-c2ccc3c(c2)C(F)(F)c2cc(-c4ccc5nc([C@@H]6CCCN6C(=O)[C@@H](NC(=O)OC)C6CCOCC6)[nH]c5c4)ccc2-3)[nH]1)C(C)C

HCID69676372

未命名化合物

PROCEDURE

实验过程

The title compound was prepared according to the method employed to prepare (S)-benzyl 1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)-4-oxopyrrolidine-2-carboxylate, except that methyl (S)-2-((S)-2-(6-(9,9-difluoro-7-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)-9H-fluoren-2-yl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-(tetrahydro-2H-pyran-4-yl)ethylcarbamate 3HCl salt was used instead of (S)-benzyl 4-oxopyrrolidine-2-carboxylate hydrochloride. MS (ESI) m/z 879.88 [M+H]+. (122 mg, 52%).

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-06a79015c5004f998e860278536f04aa
来源数据集: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US09156823B2
来源说明: uspto-grants-2015_10

反应SMILES

[CH3:1][O:2][C:3]([NH:5][C@@H:6]([CH:25]([CH3:27])[CH3:26])[C:7]([N:9]1[CH2:13][C:12](=O)[CH2:11][C@H:10]1[C:15](OCC1C=CC=CC=1)=O)=[O:8])=[O:4].Cl.Cl.Cl.[F:31][C:32]1([F:83])[C:44]2[CH:43]=[C:42]([C:45]3[CH:46]=[CH:47][C:48]4[N:52]=[C:51]([C@@H:53]5[CH2:57][CH2:56][CH2:55][N:54]5[C:58](=[O:71])[C@@H:59]([NH:66][C:67](=[O:70])[O:68][CH3:69])[CH:60]5[CH2:65][CH2:64][O:63][CH2:62][CH2:61]5)[NH:50][C:49]=4[CH:72]=3)[CH:41]=[CH:40][C:39]=2[C:38]2[C:33]1=[CH:34][C:35]([C:73]1[NH:77]C([C@@H]3CCCN3)=[N:75][CH:74]=1)=[CH:36][CH:37]=2>>[CH3:69][O:68][C:67](=[O:70])[NH:66][C@@H:59]([CH:60]1[CH2:65][CH2:64][O:63][CH2:62][CH2:61]1)[C:58]([N:54]1[CH2:55][CH2:56][CH2:57][C@H:53]1[C:51]1[NH:50][C:49]2[CH:72]=[C:45]([C:42]3[CH:41]=[CH:40][C:39]4[C:38]5[C:33](=[CH:34][C:35]([C:73]6[NH:77][C:15]([C@@H:10]7[CH2:11][CH2:12][CH2:13][N:9]7[C:7](=[O:8])[C@@H:6]([NH:5][C:3]([O:2][CH3:1])=[O:4])[CH:25]([CH3:26])[CH3:27])=[N:75][CH:74]=6)=[CH:36][CH:37]=5)[C:32]([F:83])([F:31])[C:44]=4[CH:43]=3)[CH:46]=[CH:47][C:48]=2[N:52]=1)=[O:71]