Potassium Carbonate → (S)-1-((S)-2-(5-(4-(6-(2-((S)-1-((R)-2-(methoxycarbonylamino)-2-phenylacetyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)naphthalen-2-yl)phenyl)-1H-imidazol-2-yl)thiazolidin-3-yl)-3-methyl-1-oxobutan-2-ylcarbamic acid methyl ester

Participants

Reaction Steps

Methyl (R)-2-((S)-2-(5-(6-bromonaphthalen-2-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenylethylcarbamate (155 mg, 0.29 mmol), methyl (S)-3-methyl-1-oxo-1-((S)-2-(5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-imidazol-2-yl)thiazolidin-3-yl)butan-2-ylcarbamate (195 mg, 0.37 mmol), Pd(dppf)Cl2 (43 mg, 0.058 mmol) and 2M K2CO3 (320 uL, 0.64 mmol) were all dissolved in 1,4-dioxane (1.5 mL) and the mixture was bubbled with nitrogen gas for 5 minutes. The vessel was capped, sealed and placed in an oil bath at 95° C. for 3 hours.

Provenance & Evidence