HCID 86708775, compound → HCID 67682387, compound

Participants

Reaction Steps

(R)-Benzyl 1-((S)-2-(5-(4-(6-(2-((S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)naphthalen-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carbonyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate (137 mg, 0.148 mmol) was dissolved in ethyl alcohol (5 mL) and under Argon charged with 10% Pd/C (79 mg, 0.074 mmol) in a round bottom flask. The flask was then sealed with a rubber septa and the air was removed by vacuum and replaced with H2 from a balloon. This process repeated three times and the mixture was stirred under H2 atmosphere for 18 hours. The resulting mixture was then passed through a celite plug and concentrated down on rotovap. (117 mg, 99%).

Provenance & Evidence