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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1751608Generated: October 28, 2026

Trifluoroacetic acid → Trifluoroacetic acid

https://huagongshe.com/reaction/1751608

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantHCID 178502329HCID 178502329—
SolventDichloromethaneHCID 6344—
ProductTrifluoroacetic acidHCID 6422—
ProductHCID 178502327HCID 178502327—

Reaction Steps

To (S)-1-((S)-2-(7-(5,6-bis(tert-butoxycarbonylamino)naphthalen-2-yl)-1H-naphtho[1,2-d]imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamic acid methyl ester (165 mg, 0.22 mmol) in dichloromethane (2.2 mL) was added TFA (0.5 mL) and the reaction mixture stirred for 2 hours. The solvent was removed under reduced pressure to provide title compound as TFA salts.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09156823B2
Source datasetuspto-grants-2015_10
ORD IDord-3917583975074bc2a3dd2093f69bf854
Source noteuspto-grants-2015_10