反应详情

2-tert-Butyl-7-nitro-6-phenyl-1,3-benzoxazole-4-carboxylic acid (I-223) (6.27 mmol) was dissolved in methanol (30 ml), then at room temperature, 10% palladium-carbon (430 mg) was added. The suspension was stirred at room temperature under atmospheric pressure of hydrogen for 16 hour. The catalyst was removed by filtration with washing with methanol, and the filtrate was concentrated under reduced pressure. The resulting residue was purified by middle-pressure liquid chromatography (eluent, chloroform:methanol=98:2) to obtain the entitled compound (1.274 g, 66% from I-222) as a pale brown powder.

1. customThe catalyst was removed by filtration
2. washwith washing with methanol
3. concentrationthe filtrate was concentrated under reduced pressure
4. customThe resulting residue was purified by middle-pressure liquid chromatography (eluent, chloroform:methanol=98:2)
5. customto obtain the entitled compound (1.274 g, 66% from I-222) as a pale brown powder