Diisopropylethylamine → HCID 59708434, compound

Participants

Reaction Conditions

Reaction Steps

7.2 g 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine (II) are placed in 36 ml dioxane, then first 18 ml diisopropylethylamine are added, followed by 6.1 g (R)-(−)-2-amino-3-methyl-1-butanol. The reaction mixture is heated to 100° C. until there is no further reaction, then cooled and evaporated down. The residue is treated with petroleum ether/ethyl acetate (9:1) in the ultrasound bath and the solid is suction filtered and dried. 8.3 g (III-1) are obtained in the form of a solid. Analytical HPLC (method A): RT=2.75 min

Provenance & Evidence