HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl D-2-(4-fluorophenyl)glycinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Amino(4-fluorophenyl)acetic acid | HCID 124515 | — |
| Product | Methyl D-2-(4-fluorophenyl)glycinate | HCID 11049834 | — |
Reaction Steps
4 g (R)-4-fluorophenylglycine are suspended in 80 ml of methanol. While cooling with the ice bath 3.28 ml of thionyl chloride are slowly added dropwise, so that the temperature is maintained between 15° C. and 20° C. The reaction mixture is stirred for 12 hours at ambient temperature and then evaporated to dryness. 5.1 g of the product are obtained in the form of the hydrochloride. Analytical HPLC-MS (method A): RT=0.8 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09161927B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-37981722274446f38e016a576b2c63ec |
| Source note | uspto-grants-2015_10 |