Sodium Chloride → (S)-5-dibenzylamino-1-methylpiperidin-2-one

Participants

Reaction Steps

0.500 g (S)-5-dibenzylaminopiperidin-2-one are suspended in 15 ml of tetrahydrofuran. While cooling with the ice bath 0.175 g potassium-tert-butoxide are added. The reaction mixture is then stirred for 30 minutes at ambient temperature. While cooling with the ice bath 0.095 ml methyl iodide are added. The reaction mixture is then stirred for 48 hours at ambient temperature and then combined with a saturated NaCl solution. The product is extracted with ethyl acetate. 0.450 g product are obtained in the form of an oil. Analytical HPLC-MS (method A): RT=1.07 min.

Provenance & Evidence