n-Methyl-3-nitropyridin-4-amine → 4-N-methylpyridine-3,4-diamine

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Reaction Steps

2.3 g methyl-(3-nitropyridin-4-yl)-amine are hydrogenated in 50 ml of methanol with 0.8 g Raney nickel for 2.5 h at 50° C. under 50 psi hydrogen pressure. The catalyst is filtered off and the filtrate is evaporated to dryness. The product is purified by chromatography (Alox, dichloromethane/methanol of 99/1 to 19/1). 1.55 g product are obtained in the form of a solid. m.p: 163-165° C.

Provenance & Evidence