Trifluoroacetic acid → 2-methoxy-N-(4-phenylpiperidin-4-ylmethyl)-acetamide

Participants

Reaction Steps

1 g tert-butyl 4-[(2-methoxyacetylamino)-methyl]-4-phenylpiperidine-1-carboxylate are placed in 4 ml dichloromethane. Then 1.7 ml trifluoroacetic acid are added and the mixture is stirred overnight at ambient temperature. The reaction mixture is made basic with potassium carbonate and the organic phase is evaporated to dryness. 610 mg (V-7) are obtained in the form of an oil.

Provenance & Evidence