4-Toluenesulfonyl chloride → 4-(2-p-Toluenesulfonyloxy-2-(4-tert-butylphenyl)ethoxy) quinazoline

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Reaction Steps

A 15 ml round bottom flask is charged with 4-(2-hydroxy-2-(4-tert-butylphenyl)ethoxy)quinazoline (0.25 g, 0.77 mmol) is dissolved in pyridine (5 ml). p-Toluenesulfonyl chloride (0.15 g, 0.79 mmol) is then added to it and the mixture stirred for 4 hours. The reaction mixture is diluted with ethyl acetate, washed with 5% copper sulfate solution and then with water and dried. After removing the solvent on the rotary evaporator the crude is purified by flash chromatography using silica gel (ethyl acetate/hexanes) to give the product.

Provenance & Evidence