反应详情

A 15 ml round bottom flask is charged with 4-(2-p-toluenesulfonyloxy-2-(4-tert-butylphenyl)ethoxy)quinazoline (0.3 g, 0.84 mmol). Tetrabutylammonium fluoride solution (1M in THF, 4.2 ml, 4.2 mmol) is then added to it and the solution is heated at reflux for 60 minutes. The mixture is then cooled and water is added to it. It is then extracted with dichloromethane, washed with water and dried. The crude obtained after concentration is purified by silica gel flash chromatography (ethyl acetate/hexanes) to obtain the desired compound.

1. temperaturethe solution is heated
2. temperatureat reflux for 60 minutes
3. temperatureThe mixture is then cooled
4. extractionIt is then extracted with dichloromethane
5. washwashed with water
6. customdried
7. customThe crude obtained
8. concentrationafter concentration
9. customis purified by silica gel flash chromatography (ethyl acetate/hexanes)