Acetophenone → 1-Phenylethanol, (R)-

Participants

Reaction Conditions

Reaction Steps

A ruthenium complex RuCl[(R,R)-Tsdpen] (p-cymene) (6.4 mg, 0.01 mmol), potassium formate (1.0 g, 12 mmol) and acetophenone (1.20 g, 10 mmol, substrate/catalyst ratio=1000) were set in a 20 mL glass Schlenk-type reaction tube under an argon atmosphere. Methanol (6 mL) was added thereto and stirred at 50° C. for 24 hours to give (R)-1-phenylethanol at 100% yield and 96.2% ee optical purity.

Provenance & Evidence