Formic Acid → (1S)-1-(3-CHLOROPHENYL)ETHANOL

Participants

Reaction Conditions

Reaction Steps

A ruthenium complex RuCl[(S,S)-BnSO2dpen] (mesitylene) (1.2 mg, 0.002 mmol), potassium formate (1.0 g, 12 mmol), formic acid (138 mg, 3 mmol) and 3′-chloroacetophenone (1.55 g, 10 mmol, substrate/catalyst ratio=5000) were set in a 20 mL glass Schlenk-type reaction tube under an argon atmosphere. Methanol (6 mL) was added thereto and stirred at 50° C. for 24 hours to give (S)-1-(3′-chlorophenyl)ethanol at 85% yield and 96.5% ee optical purity.

Provenance & Evidence