HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrazole → Ethyl 4-(1H-pyrazol-1-YL)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrazole | HCID 1048 | — |
| Reactant | Ethyl 4-iodobenzoate | HCID 142891 | — |
| Product | Ethyl 4-(1H-pyrazol-1-YL)benzoate | HCID 973146 | — |
Reaction Steps
Following General Procedure A (90° C., 30 hours), 1H-pyrazole (205 mg, 3.0 mmol) is coupled with ethyl 4-iodobenzoate (336 μL, 2.0 mmol). The crude brown oil is purified by flash chromatography on silica gel (eluent: dichloromethane/hexanes=80/20) to provide 400 mg (93% isolated yield) of the desired product as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09162953B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-e6910f2459794195ba32d370454e564f |
| Source note | uspto-grants-2015_10 |