HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrazole → 4-(1-Pyrazolyl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrazole | HCID 1048 | — |
| Reactant | Benzonitrile, 4-bromo- | HCID 12162 | — |
| Product | 4-(1-Pyrazolyl)benzonitrile | HCID 12079629 | — |
Reaction Steps
Following General Procedure A (90° C., 30 hours), 1H-pyrazole (205 mg, 3.0 mmol) is coupled with 4-bromobenzonitrile (364 mg, 2.0 mmol). The crude brown oil is purified by flash chromatography on silica gel (eluent: dichloromethane/hexanes=50/50) to provide 330 mg (98% isolated yield) of the desired product as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09162953B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-80de8972aa964ee59fe6ed32ba9f08df |
| Source note | uspto-grants-2015_10 |