HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrazole → 1-p-Tolyl-1H-pyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrazole | HCID 1048 | — |
| Reactant | 4-Bromotoluene | HCID 7805 | — |
| Product | 1-p-Tolyl-1H-pyrazole | HCID 809797 | — |
Reaction Steps
Following General Procedure A (125° C., 24 hours), 1H-pyrazole (102 mg, 1.5 mmol) is coupled with 1-bromo-4-methylbenzene (122 μL, 1.0 mmol). The crude brown oil is purified by flash chromatography on silica gel (eluent: dichloromethane/hexanes=70/30) to provide 90 mg (57% isolated yield) of the desired product as an uncolored oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09162953B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-e838b52e468c4130b8200b8f644fde57 |
| Source note | uspto-grants-2015_10 |