HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrazole → 1-(4-(TRIFLUOROMETHYL)PHENYL)-1H-PYRAZOLE
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrazole | HCID 1048 | — |
| Reactant | 1-Chloro-4-(trifluoromethyl)benzene | HCID 7394 | — |
| Product | 1-(4-(TRIFLUOROMETHYL)PHENYL)-1H-PYRAZOLE | HCID 11218094 | — |
Reaction Steps
Following General Procedure A (140° C., 24 hours), 1H-pyrazole (102 mg, 1.5 mmol) is coupled with 1-chloro-4-(trifluoromethyl)benzene (134 μL, 1.0 mmol). The crude brown oil is purified by flash chromatography on silica gel (eluent: dichloromethane/hexanes=50/50) to provide 80 mg (38% isolated yield) of the desired product as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09162953B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-b8c3e9a1055949e8986ee55e31a19680 |
| Source note | uspto-grants-2015_10 |