HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrazole → 4-(1H-Pyrazol-1-yl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrazole | HCID 1048 | — |
| Reactant | 4-Iodoaniline | HCID 10893 | — |
| Product | 4-(1H-Pyrazol-1-yl)aniline | HCID 594274 | — |
Reaction Steps
Following General Procedure A (125° C., 24 hours), 1H-pyrazole (102 mg, 1.5 mmol) is coupled with 4-iodoaniline (220 mg, 1.0 mmol). The crude brown oil is purified by flash chromatography on silica gel (eluent: dichloromethane/hexanes=50/50) to provide 90 mg (57% isolated yield) of the desired product as an orange solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09162953B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-1d2364af15fd47abb3365a9f9af9c7f3 |
| Source note | uspto-grants-2015_10 |