Iodobenzene → 1-Phenylpyrrolidin-2-one

HRID 1751928Notes

Reaction equation

HRID 1751928 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].I[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>>[C:8]1([N:1]2[CH2:5][CH2:4][CH2:3][C:2]2=[O:6])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 11575IodobenzeneHCID 120252-Pyrrolidone

Product 1

HCID 783751-Phenylpyrrolidin-2-one

Procedure

Following General Procedure A (90° C., 30 hours), pyrrolidin-2-one (116 μL, 1.5 mmol) is coupled with iodo-benzene (112 μL, 1.0 mmol). The crude brown oil is purified by flash chromatography on silica gel (eluent: dichloromethane/ethylacetate=80/20) to provide 130 mg (81% isolated yield) of the desired product as a yellow solid.

Workup

  1. customThe crude brown oil is purified by flash chromatography on silica gel (eluent: dichloromethane/ethylacetate=80/20)
  2. customto provide

Sources & evidence

ORD record
ord-6664b49d301b48b2b5a06832bf55645b
Source dataset
uspto-grants-2015_10
Patent number
US09162953B2

Reaction notes

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