2-Iodobenzylic alcohol → 2-Iodobenzaldehyde

HRID 1751969Notes

Reaction equation

HRID 1751969 reaction equation
[I:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][OH:5]>ClCCl.[O-2].[Mn+2]>[I:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[O:5]

Participants

4

Reactant 1

HCID 1076292-Iodobenzylic alcohol

Product 1

HCID 6434392-IodobenzaldehydeYield 91%

Reagents, catalysts & solvents 2

HCID 160959Manganese oxideCatalystHCID 6344DichloromethaneSolvent

Procedure

In a flask, 2-iodobenzyl alcohol (4 g, 17.09 mmol) was dissolved in dichloromethane (MC, 85 ml), and then, manganese oxide (MnO2, 14.86 g, 170.92 mmol) was added thereto. The obtained reaction product was stirred under the reflux condition. When the reaction was completed, the obtained reaction product was cooled to the room temperature, and then, fiteated and concentrated using celite, to obtain the title compound (3.6 g, yield 91%).

Workup

  1. customThe obtained reaction product
  2. customthe obtained reaction product
  3. concentrationfiteated and concentrated

Sources & evidence

ORD record
ord-357e9d5d5d88487eb82fd0b5cf3e7206
Source dataset
uspto-grants-2015_10
Patent number
US09162975B2

Reaction notes

Loading…