Methanol → HCID 57762512, compound

HRID 1752079Notes

Reaction equation

S(Cl)(Cl)=O.[F:5][C:6]1[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[C:7]=1[C:8]([NH:10][CH:11]([CH2:15][CH:16]=[CH2:17])[C:12]([OH:14])=[O:13])=[O:9].[CH3:23]O>>[CH3:23][O:13][C:12](=[O:14])[CH:11]([NH:10][C:8](=[O:9])[C:7]1[C:6]([F:5])=[CH:21][CH:20]=[CH:19][C:18]=1[F:22])[CH2:15][CH:16]=[CH2:17]

Participants

Reactant 3

HCID 887Methanol

HCID 24386Thionyl Chloride

HCID 66911963HCID 66911963, compound

Product 1

HCID 57762512HCID 57762512, compound

Procedure

In the same manner as in Reference Example 35-(1), allylglycine (285 mg) was reacted with 2,6-difluorobenzoyl chloride (0.374 ml) to obtain 2-(2,6-difluorobenzamido)pent-4-enoic acid (471 mg). (2) In the same manner as in Reference Example 35-(2), thionyl chloride (0.242 ml) was reacted with a solution of 2-(2,6-difluorobenzamido)pent-4-enoic acid (471 mg) in methanol (20 ml) to obtain 2-(2,6-difluorobenzamido)pent-4-enoic acid methyl ester (430 mg).

Sources & evidence

ORD record: ord-c6d2d9d437c44a5c9a2bc4be314a32f9
Source dataset: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09162988B2

Reaction notes

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