Ether hydrochloride → HCID 86665975, compound

HRID 1752113Notes

Reaction equation

[CH2:1]([O:4][NH:5][C:6]1[N:11]=[C:10]([NH:12][CH2:13][CH2:14][CH3:15])[N:9]=[C:8]([NH:16][CH2:17][CH2:18][CH3:19])[N:7]=1)[CH:2]=[CH2:3].[ClH:20].C(OCC)C>>[ClH:20].[CH2:1]([O:4][NH:5][C:6]1[N:11]=[C:10]([NH:12][CH2:13][CH2:14][CH3:15])[N:9]=[C:8]([NH:16][CH2:17][CH2:18][CH3:19])[N:7]=1)[CH:2]=[CH2:3]

Participants

Reactant 2

HCID 10953452Ether hydrochloride

HCID 57377802HCID 57377802, compound

Product 1

HCID 86665975HCID 86665975, compound

Procedure

O-Allyl-N-(4,6-bis-n-propylamino-[1,3,5]triazin-2-yl)-hydroxylamine hydrochloride (XLIV) was prepared from O-allyl-N-(4,6-bis-n-propylamino-[1,3,5]triazin-2-yl)-hydroxylamine (XLIII) and 2M HCl/ethyl ether as described in Example 12. 400 MHz 1H NMR (DMSO-d6, ppm) 11.7-10.0 (1H, m), 7.9-7.1 (2H, m), 6.09-5.92 (1H, m), 5.39-5.18 (2H, m), 4.35 (2H, d, J=6.0 Hz), 3.28-3.11 (4H, m), 1.56-1.42 (4H, m), 0.91-0.81 (6H, m). ESI-MS (m/z): 267 [M+H]+. MP: 130-132° C.

Sources & evidence

ORD record: ord-da87951e78f54711943b70200fefb161
Source dataset: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09162992B2

Reaction notes

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