Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

(R)-tert-butyl 3-(6-chloro-1-methyl-2-oxo-1H-imidazo[4,5-b]pyridin-3(2H)-yl)pyrrolidine-1-carboxylate (109 mg) was dissolved in CH2Cl2 (3 mL) and 4 M HCl in dioxane (1 mL, 4 mmol) was added. The mixture was stirred at rt for 3 h and concentrated to give (R)-6-chloro-1-methyl-3-(pyrrolidin-3-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one as its HCl salt (78 mg, 87%). Method 1 tR=0.77 min, m/z=253.

Provenance & Evidence