HCID 67479577, compound → HCID 67480057, compound

Participants

Reaction Conditions

Reaction Steps

Crude (R)-tert-butyl 3-((2-acetamido-6-chlorophenyl)amino)pyrrolidine-1-carboxylate (148 mg) was dissolved in glacial HOAc (20 mL) and heated at 70° C. for 1 day. The mixture was concentrated. The residue was taken up in EtOAc (100 mL), washed with satd aq NaHCO3 (10 mL) and brine (10 mL), and dried over Na2SO4. Removal of the solvent left a brown oil (133 mg) which was purified by chromatography on a 12-g silica gel cartridge eluted with a 0-100% EtOAc in hexanes gradient to afford (R)-tert-butyl 3-(7-chloro-2-methyl-1H-benzo[d]imidazol-1-yl)pyrrolidine-1-carboxylate (59 mg, 18%) as a brown oil. LC-MS Method 1 tR=1.42 min, m/z=336.

Provenance & Evidence