HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 3-(4-methylthiazol-2-yl)pyrrolidine-1-carboxylate → 4-Methyl-2-(pyrrolidin-3-yl)-1,3-thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 3-(4-methylthiazol-2-yl)pyrrolidine-1-carboxylate | HCID 23532020 | — |
| Solvent | Trifluoroacetic acid methylene chloride | HCID 21863450 | — |
| Product | 4-Methyl-2-(pyrrolidin-3-yl)-1,3-thiazole | HCID 12150004 | 98% |
Reaction Steps
To a solution of tert-butyl 3-(4-methylthiazol-2-yl)pyrrolidine-1-carboxylate (90 mg, 0.34 mmol) in TFA/CH2Cl2 (20%, 2 mL) was stirred at rt for 1 h and concentrated to give 4-methyl-2-(pyrrolidin-3-yl)thiazole (55 mg, 98%) as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09163012B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-69cb5bceaa324528bb9a306dc7a86425 |
| Source note | uspto-grants-2015_10 |