Methanol → HCID 58171618, compound

Participants

Reaction Conditions

Reaction Steps

Sodium (362 mg, 15.75 mmol) was added portionwise to methanol (15 mL) at 22° C. until a homogeneous solution was obtained. The solution was then treated with 2-(1-benzyl-pyrrolidin-3-yl)-5-bromo-pyrimidine (1 g, 3.15 mmol) and heated in a sealed tube at 110° C. for 24 h. The mixture was cooled, concentrated in vacuo. The residue was purified by column chromatography to afford 2-(1-benzylpyrrolidin-3-yl)-5-methoxypyrimidine (230 mg 27.2%) as a yellow oil.

Provenance & Evidence