Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

(R)-tert-butyl 3-(3,5-difluoropyridin-2-yloxy)pyrrolidine-1-carboxylate (0.83 g, 2.75 mmol) was dissolved in 4M HCl in dioxane (5 mL, 200 mmol) and stirred overnight at rt. The mixture was concentrated to leave (R)-3,5-difluoro-2-(pyrrolidin-3-yloxy)pyridine as its HCl salt (722 mg, quant). LC-MS Method 1 tR=0.58 min, m/z=201.

Provenance & Evidence