HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloro-2-(pyrrolidin-3-YL)pyrimidine → 1-Hydroxy-4-adamantyl 3-(5-chloropyrimidin-2-yl)pyrrolidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloro-2-(pyrrolidin-3-YL)pyrimidine | HCID 55262356 | — |
| Reactant | 1-Hydroxy-4-adamantyl chloroformate | HCID 58171499 | — |
| Product | 1-Hydroxy-4-adamantyl 3-(5-chloropyrimidin-2-yl)pyrrolidine-1-carboxylate | HCID 49835644 | — |
Reaction Steps
The title compound was prepared following a procedure analogous to that described in Example 19 Step 1 using 1-hydroxy-4-adamantyl chloroformate solution and 5-chloro-2-(pyrrolidin-3-yl)pyrimidine. Two isomers were separated by prep HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09163012B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-3c164ad7eac44f93a60cd183bef885c8 |
| Source note | uspto-grants-2015_10 |