Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 4-Fluorophenol | HCID 9732 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-Bromo-5-iodopyridine | HCID 4738271 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 71283746 | HCID 71283746 | — |
Reaction Steps
A mixture of 4-fluorophenol (1.12 g, 10 mmol), 2-bromo-5-iodopyridine (2.84 g, 10 mmol) and Cs2CO3 (3.83 g, 10 mmol) in DMF was stirred at 120° C. for 4 hrs. The reaction was worked up with EtOAc to give 2-(4-fluoro-phenoxy)-5-iodo-pyridine which was used for next step without further purification (crude yield 100%, yellowish solid). LC/MS: m/z=317 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09163008B2 |
|---|
| Source dataset | uspto-grants-2015_10 |
|---|
| ORD ID | ord-97b9ded4bf684e819de151b0c85898a9 |
|---|
| Source note | uspto-grants-2015_10 |
|---|
