Ammonia → HCID 86689151, compound

Participants

Reaction Steps

To a solution of (S)-2-methyl-propane-2-sulfinic acid [(R)-1-(6-bromo-3-fluoro-pyridin-2-yl)-2,2-difluoro-3-hydroxy-1-(2-methoxy-ethyl)-propyl]amide (1.50 g, 3.33 mmol) in methanol (8.4 ml) was added 2M HCl in diethyl ether (6.56 ml, 13.11 mmol). The reaction mixture was stirred for 1.5 h at room temperature. 7 M ammonia in methanol (2.7 ml) was added to the reaction mixture and the resulting colourless suspension was evaporated in vacuo. The remaining solid was triturated with warm dichloromethane, cooled to rt, filtered and rinsed with dichloromethane. The filtrate was evaporated affording the title compound which was used without purification in the next step. 1.42 g colourless, viscous oil. 100% yield.

Provenance & Evidence