Trifluoroacetic acid → HCID 71529262, compound

Participants

Reaction Steps

To a solution of ((R)-4-{6-[(3-chloro-5-trifluoromethyl-pyridine-2-carbonyl)-amino]-3-fluoro-pyridin-2-yl}-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-yl)-carbamic acid tert-butyl ester (180 mg, 0.317 mmol) in DCM (1.5 ml) was added TFA (0.5 ml) and the mixture was stirred at it for 1 h. The reaction mixture was poured on 10% aq. Na2CO3, more DCM was added and the layers were separated. The aq. phase was extracted with DCM (3×), the combined DCM phases were dried with K2CO3 and evaporated to provide the title compound as colorless solid.

Provenance & Evidence