Hydrochloric Acid → Sodium Chloride

Participants

Reaction Steps

To a solution of 3-(di-tert-butoxycarbonyl-amino)-5-difluoromethyl-pyrazine-2-carboxylic acid methyl ester (75 mg, 0.186 mmol) in THF (2 ml) was added dropwise 1N NaOH (0.205 ml, 0.205 mmol) and the reaction mixture was stirred for 1.5 h. To the mixture was added 1N HCl (0.186 ml, 0.186 mmol) after stirring for 5 min toluene was added and the solvents were evaporated to provide the title compound together with sodium chloride as colorless solid. The mixture was used for coupling reactions without further purification.

Provenance & Evidence