Hydrochloric Acid → Lithium Chloride

Participants

Reaction Steps

To a solution of 3-amino-5-(3-methoxy-prop-1-ynyl)-pyridine-2-carboxylic acid methyl ester (263 mg, 1.2 mmol) in THF (6 ml) was added 1N lithium hydroxide (1.32 ml, 1.32 mmol) at 0° C. and the mixture was stirred at room temperature for 2 h. To the mixture was added 1N HCl (1.2 ml, 1.2 mmol) at 0° C., after stirring for 5 min toluene was added and the solvents were evaporated to provide the title compound together with lithium chloride as an off-white solid. The mixture was used for coupling reactions without further purification.

Provenance & Evidence