Tetrahydro-2-(2-propynyloxy)-2H-pyran → HCID 71271170, compound

HRID 1752490Notes

Reaction equation

HRID 1752490 reaction equation
C[O:2][C:3]([C:5]1[C:10]([Cl:11])=[CH:9][C:8](Br)=[CH:7][N:6]=1)=[O:4].[CH2:13]([O:16][CH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][O:18]1)[C:14]#[CH:15]>>[Cl:11][C:10]1[C:5]([C:3]([OH:2])=[O:4])=[N:6][CH:7]=[C:8]([C:15]#[C:14][CH2:13][O:16][CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][O:18]2)[CH:9]=1

Participants

3

Reactant 2

HCID 98609Tetrahydro-2-(2-propynyloxy)-2H-pyranHCID 46311201Methyl 5-bromo-3-chloropyridine-2-carboxylate

Product 1

HCID 71271170HCID 71271170, compound

Procedure

The title compound was prepared by an analogous procedure to Acid-xx using 5-bromo-3-chloro-pyridine-2-carboxylic acid methyl ester instead of 3-amino-5-bromo-pyridine-2-carboxylic acid methyl ester and 2-prop-2-ynyloxy-tetrahydro-pyran instead of 3-methoxy-propyne [Acid-xx step a)].

Sources & evidence

ORD record
ord-50b9e1549a714ceeb00f3978ea28c363
Source dataset
uspto-grants-2015_10
Patent number
US09163011B2

Reaction notes

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