HCID 68109996, compound → HCID 68110138, compound

HRID 1752495Notes

Reaction equation

HRID 1752495 reaction equation
[F:1][CH:2]([F:15])[C:3]1[CH:4]=[C:5]([N+:12]([O-])=O)[C:6]([C:9]([OH:11])=[O:10])=[N:7][CH:8]=1>CCO.[Ni]>[NH2:12][C:5]1[C:6]([C:9]([OH:11])=[O:10])=[N:7][CH:8]=[C:3]([CH:2]([F:15])[F:1])[CH:4]=1

Participants

4

Reactant 1

HCID 68109996HCID 68109996, compound

Product 1

HCID 68110138HCID 68110138, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

To a solution of 265 mg (1.22 mmol) 5-difluoromethyl-3-nitro-pyridine-2-carboxylic acid in EtOH was added 50 mg Raney-Nickel (Degussa B113W) and the reaction mixture was kept shaking under a hydrogen atmosphere for 16 h. The catalyst was filtered off (Celite) and washed with EtOH and the filtrate was evaporated to provide the title compound as off-white solid.

Workup

  1. filtrationThe catalyst was filtered off (Celite)
  2. washwashed with EtOH
  3. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-fecd358641ad48c48fa15ff2ea6ed2fb
Source dataset
uspto-grants-2015_10
Patent number
US09163011B2

Reaction notes

Loading…