反应详情

温度

85 °C

To a solution of 3-Chloro-5-(2,2-difluoro-ethoxy)-pyridine-2-carbonitrile (0.202 g, 0.878 mmol) in dioxane (4 ml) was added 4N NaOH (2.2 ml, 8.8 mmol) and the resulting reaction mixture was stirred for 28 h at 85° C. The reaction mixture was diluted with water and extracted with EtOAc. The aqueous phase was acidified with 4N HCl and evaporated to dryness. The title compound was extracted with DCM/MeOH (9/1), pushed through a plug of Celite and was obtained after evaporation as a light yellow solid.

1. customthe resulting reaction mixture
2. extractionextracted with EtOAc
3. customevaporated to dryness
4. extractionThe title compound was extracted with DCM/MeOH (9/1)
5. customwas obtained
6. customafter evaporation as a light yellow solid