Sodium Bicarbonate → HCID 86689173, compound

Participants

Reaction Steps

A solution of 3-amino-6-chloro-5-(1-ethoxy-vinyl)-pyrazine-2-carboxylic acid methyl ester (46 mg, 0.190 mmol) and para-toluenesulfonic acid monohydrate (73.8 mg, 0.388 mmol) in THF (2.85 ml) was stirred at rt for 1 h. Saturated aq. NaHCO3 was added and the mixture was extracted twice with DCM. The combined organic layers were washed with brine, dried with Na2SO4, filtered and concentrated under reduced pressure to obtain a yellow solid (46 mg). This material was used for the next step without further purification.

Provenance & Evidence